Properties of non‐canonical GC base pairs and their relations with mechanochemical cleavage of DNA are analyzed. A hypothesis of the involvement of the transient GC wobble base pairs both in the mechanisms of the mechanochemical cleavage of DNA and epigenetic mechanisms involving of 5‐methylcytosine, is proposed. The hypothesis explains the increase in the frequency of the breaks of the sugar‐phosphate backbone of DNA after cytosines, the asymmetric character of these breaks, and an increase in break frequency in CpG after cytosine (...) methylation. As an alternative hypothesis, probable implication of GC+ Hoogsteen base pairs is considered, which now exemplify the best‐studied non‐canonical GC base pairs in the DNA double helix. Also see the video abstract here https://youtu.be/EUunVWL0ptw. (shrink)

As moral standards, natural law and the notion of properly functioning human nature have persisted in Western cultures from the dawn of civilization. Medieval Christians developed it in their theologies. However, Enlightenment criticism of medieval thought undermined the credibility of natural law and its authority for modern man. Jacques Maritain developed a rational foundation for natural law and sought to provide objectivity to natural law precepts. His theory also reestablishes the divine authority of natural law for a world without faith. (...) Maritain locates the primary disclosure of natural law in the conscience’s moral reflection in a controversial act of pre-conceptual or non-conceptual knowledge called connatural knowledge. (shrink)

The notion of a properly functioning human nature as a moral standard is a tenet of Western culture and is at the core Western humanism, Christian moral teaching, and natural law theory. Although these traditions recognize that the virtue of justice is exercised by giving one’s neighbor his due, they did not explore a person’s legitimate claims to goods in a modern theory of human rights. Enlightenment thinkers, as materialists and atheists, theorized that human rights are not related to God (...) or human nature but are privileges granted by government. Jacques Maritain developed theories of natural law and human rights. Maritain’s theory of human rights, employing a Thomistic methodology and founded on God and nature, is applicable to contemporary disputes, such as claims to a right to “same-sex” marriage. (shrink)

For many economists, including those who have made the most marked contribution to the development of the discipline, their work has to be understood in the context of the rhetorical strategy they were pursuing – what they wanted to persuade us of and how they wanted to do it. The paper identifies two fundamental rhetorical strategies of laissez-faire resting on entirely distinct ontological foundations. What distinguishes these two strategies is the way they articulate the individual with the general interest, how (...) they relate the micro to the macro. The two strategies discussed in the paper are characterised by the stance they take on a fundamental ontological issue, the way in which the things which appear to us in the world are related to the things or matters which compose them. A reductionist approach suggests that we can understand an entity at one level as a congeries. An entity in this view is just an aggregate of entities at a lower, substrate level – a purely external unity. The properties and behaviour of an entity can then be understood in terms of the properties and behaviour of the constituent lower-level components, taken in isolation. In this approach, phenomena at some level are regarded as having just the qualities enjoyed by its lower-level, substrate elements, writ large. The contrary, holistic, stance is to view the qualities of phenomena at one level as emergent at that level, and to assert that an entity can be understood as a product of the inter-relations between its component parts. We have, then, a pair of contrasted approaches: a polarity which is productive in the study of schools of thought, of competing methodologies, and of rhetorical strategies in economics. The paper applies this approach to the work of Smith, Keynes, Hayek, Lucas and Friedman. (shrink)

For many economists, including those who have made the most marked contribution to the development of the discipline, their work has to be understood in the context of the rhetorical strategy they were pursuing – what they wanted to persuade us of and how they wanted to do it. The paper identifies two fundamental rhetorical strategies of laissez-faire resting on entirely distinct ontological foundations. What distinguishes these two strategies is the way they articulate the individual with the general interest, how (...) they relate the micro to the macro. The two strategies discussed in the paper are characterised by the stance they take on a fundamental ontological issue, the way in which the things which appear to us in the world are related to the things or matters which compose them. A reductionist approach suggests that we can understand an entity at one level as a congeries. An entity in this view is just an aggregate of entities at a lower, substrate level – a purely external unity. The properties and behaviour of an entity can then be understood in terms of the properties and behaviour of the constituent lower-level components, taken in isolation. In this approach, phenomena at some level are regarded as having just the qualities enjoyed by its lower-level, substrate elements, writ large. The contrary, holistic, stance is to view the qualities of phenomena at one level as emergent at that level, and to assert that an entity can be understood as a product of the inter-relations between its component parts. We have, then, a pair of contrasted approaches: a polarity which is productive in the study of schools of thought, of competing methodologies, and of rhetorical strategies in economics. The paper applies this approach to the work of Smith, Keynes, Hayek, Lucas and Friedman. (shrink)

Determining the personhood of the human embryo is critical to advancing an informed and reasoned public policy debate over abortion and human embryo research. Many defenders of life—the Vatican included—have withheld recognition of the personhood of the embryo in order to avoid making an explicitly philosophical statement. This essay considers current embryological evidence from a philosophical (i.e., Aristotelian-Thomistic) point of view. This essay also addresses certain contemporary and antithetical philosophical biases. A demonstration then shows that the embryo is the fully (...) formed human person’s initial stage of development consisting of a rational soul that possesses the power of intellect and a commensurate body that is capable of developing into the fully formed human person. National Catholic Bioethics Quarterly 9.4 (Winter 2009): 689–693. (shrink)

The purpose of this paper is to discuss how women managers themselves interpret the factors that constrain and those that facilitate management careers for women. We will do this by first reviewing some of the interpretations that have been put forward in the academic literature to explain the relatively small number of women managers and particularly the small number of very senior women managers. In the light of these interpretations, we will examine the opinions of a sample of intermediate and (...) senior women managers in the public and private sectors in Ontario and Québec. More specifically we will look at their answers to questions about what blocks and what facilitates management careers for women generally and what obstacles they themselves have met. We will then compare their interpretations of their own career development with the interpretations that exist in the literature. (shrink)

ABSTRACT:In a series of reports the United Nations Special Representative on the issue of Human Rights and Transnational Corporations has emphasized a tripartite framework regarding business and human rights that includes the state “duty to protect,” the TNC “responsibility to respect,” and “appropriate remedies” for human rights violations. This article examines the recent history of UN initiatives regarding business and human rights and places the tripartite framework in historical context. Three approaches to human rights are distinguished: moral, political, and legal. (...) It is argued that the tripartite framework’s grounding of the responsibility of TNCs to respect human rights is properly understood as moral and not merely as a political or legal duty. A moral account of the duty of TNCs to respect basic human rights is defended and contrasted with a merely strategic approach. The main conclusion of the article is that only a moral account of the basic human rights duties of TNCs provides a sufficiently deep justification of “the corporate responsibility to respect human rights” feature of the tripartite framework. (shrink)

Good explanations are not only true or probably true, but are also relevant to a causal question. Current models of causal explanation either only address the question of the truth of an explanation, or do not distinguish the probability of an explanation from its relevance. The tasks of scenario construction and conversational explanation are distinguished, which in turn shows how scenarios can interact with conversational principles to determine the truth and relevance of explanations. The proposed model distinguishes causal discounting from (...) causal backgrounding , and makes predictions concerning the differential effects of contextual information about alternative explanations on: (a) the kind of mental models constructed; (b) belief revision about probable cause; and (c) the perceived quality of a focal explanation. Four experiments are reported that test these predictions. The significance of the notion of explanatory relevance for research on causal explanation is then discussed. (shrink)

In this dissertation I develop a general theory of coercion that allows one to distinguish cases of interpersonal coercion from cases of persuasion or manipulation, and cases of institutional coercion from cases of oppression. The general theory of coercion that I develop includes as one component a theory of second-order coercion. Second-order coercion takes place whenever one person intentionally impairs the formation of the second-order desires of another person, or constrains them after their formation, in a way that frustrates or (...) eliminates the possibility of the victim fulfilling certain of his or her first-order desires. The concept of second-order coercion is important because it suggests that a person's autonomy may be violated in ways that have not been previously recognized. In this dissertation I argue that the unique feature of all cases of coercion is that the alternatives available to the victim, with regard to the formation of his or her will, are intentionally constrained by another person in a way that violates the victim's autonomy. A general theory of coercion should be able to explain how institutions may be understood as coercive. I argue that if institutions are understood as social practices maintained for the purpose of achieving some end, then they may be properly understood as capable of coercion. ;This theory of coercion allows me to make two arguments concerning moral responsibility. First, I argue that current discussions of moral responsibility are inadequate because they fail to take seriously the claim that a person may be responsible, at least in part, for having the beliefs and desires that make a particular action a case of coercion. Second, I argue that discussions of moral responsibility are inadequate because they fail to recognize that an agent may not be responsible for the state of his or her will because he or she may have been coerced in a way that has not been previously recognized. (shrink)

This paper explores a variety of kinds of apparent disagreement of which it may be held that they involve failure to disagree in that, at least in some broad sense, the disputants use the same words to express different meanings or concepts. It is argued that it is hard to rebut the claim that some apparent disagreements about personal identity fall into a particular sub-category of this broad type. I conclude both that a "constrained" relativism which I call "quasi-relativism" is (...) appropriate in regard to some central personal-identity debates, and also that, in order to avoid the lamentable conclusion that there is no real disagreement at all in these debates, we should embrace the idea that there is a non-cognitive element in personal identity claims, in virtue of the tight conceptual relations between personal identity claims and value claims of various kinds. (shrink)

I consider Kant’s use of claims about “nature’s ends” in his arguments to establish maxims of homosexual sex, masturbation, and bestiality as constituting “unnatural” sexual vices, which are contrary to one’s duties to oneself as an animal and moral being. I argue, first, that the formula of humanity is the principle best suited for understanding duties to oneself as an animal and moral being; and second, that although natural teleology is relevant to some degree in specifying these duties, it cannot (...) play a sufficiently robust role to establish Kant’s conclusion. I also discuss what the formula of humanity (along with warranted attention to natural teleology) suggests about the morality of homosexual sex, masturbation, and bestiality. (shrink)

After sketching some aspects of truthmaker doctrines and "truthmaker projects", and canvassing some prima facie objections to the latter, I turn to an issue which might seem to involve confusion about the nature of character of truthmakers if such there be, viz for statements of identity and (specially) distinctness. The real issue here is versions of the Identity of Indiscernibles. I discuss ways of discriminating versions, which are almost certainly true but trivial, which almost certainly substantive but false, and explore (...) an interesting intermediate possibility which might if developed yield a plausibly true yet not-entirely-trivial version of the doctrine: it is equivalent to what I call "the Denial of Bare Distinctness". (shrink)

We build an א₁-categorical but not א₀-categorical theory whose only computably presentable model is the saturated one. As a tool, we introduce a notion related to limitwise monotonic functions.

I critically discuss both the particular doctrinal and general meta-philosophical or methodological tenets of Mark Johnston's paper "Human Beings", attending to several weaknesses in his argument. One of the most important amongst them is an apparent reliance on a substitution of identicals within an intensional context as he argues that continuity of functioning brain is essential to the persistence of "Human Beings" as allegedly singled out by his methodology; another equally important is a simple lacuna in place of an argument (...) that candidate entities for re-identification by means we take for granted in the case of persons cannot be what I call "mentalistically" individuated. (shrink)

Despite its importance in various fields, analogical reasoning has not yet received a unified formal representation. Our contribution proposes a general scheme of inference that is compatible with different types of logic (deductive, probabilistic, non-monotonic). Firstly, analogical assessment precisely defines the similarity of two objects according to their properties, in a relative rather than absolute way. Secondly, analogical inference transfers a new property from one object to a similar one, thanks to an over-hypothesis linking two sets of properties. The belief (...) strength in the conclusion is then directly related to the belief strength in this meta-hypothesis. (shrink)

Recently the attempt has been made to demonstrate Heidegger's relevance to the concerns of analytic philosophers. A focus for this effort has been the criticism in his early work of Cartesian ontology. While a number of important works have mapped out this area of Heidegger's thought, a crucial task has not been carried out, namely that of assessing how Heidegger can accommodate those phenomena which motivate the Cartesian to adopt his highly counter-intuitive ontology. As long as we fail to examine (...) how Heidegger's early ontology copes with the possibilities of error and of hallucination, the suspicion will remain that Heidegger is simply insensitive to those phenomena on which the Cartesian focuses. Neither Heidegger nor the Cartesian have been done any favours by commentators showing little inclination to bring the opponents into closer combat. This paper attempts to correct that omission. (shrink)

Drawing on an ethnographic study of the installation and maintenance of Paris subway wayfinding system, this article attempts to discuss and specify previous claims that highlight stability and immutability as crucial aspects of material ordering processes. Though in designers’ productions, subway signs have been standardized and their consistency has been invested in to stabilize riders’ environment, they appear as fragile and transforming entities in the hands of maintenance workers. These two situated accounts are neither opposite nor paradoxical: they enact different (...) versions of subway signs, the stabilization of which goes through the acknowledgment of their vulnerability. Practices that deal with material fragility are at the center of what we propose, following Annemarie Mol and Maria Puig de la Bellacasa, to term a care of things. Foregrounding such a care of things is a way to surface a largely overlooked dimension of material ordering and to renew how maintainability issues are generally tackled. (shrink)

Since its origin in the early 20th century, the Modern Synthesis theory of evolution has grown to become the orthodox view on the process of organic evolution. Its central defining feature is the prominence it accords to genes in the explanation of evolutionary dynamics. Since the advent of the 21st century, however, the Modern Synthesis has been subject to repeated and sustained challenges. These are largely empirically driven. In the last two decades, evolutionary biology has witnessed unprecedented growth in the (...) understanding of those processes that underwrite the development of organisms and the inheritance of characters. The empirical advances usher in challenges to the conceptual foundations of evolutionary theory. The extent to which the new biology challenges the Modern Synthesis has been the subject of lively debate. Many current commentators charge that the new biology of the 21st century calls for a revision, extension, or wholesale rejection of the Modern Synthesis Theory of evolution. Defenders of the Modern Synthesis maintain that the theory can accommodate the exciting new advances in biology. The original essays collected in this volume survey the various challenges to the Modern Synthesis arising from the new biology of the 21st century. The authors are evolutionary biologists, philosophers of science, and historians of biology from Europe and North America. Each of the essays discusses a particular challenge to the Modern Synthesis treatment of inheritance, development, or adaptation. Taken together, the essays cover a spectrum of views, from those that contend that the Modern Synthesis can rise to the challenges of the new biology, with little or no revision required, to those that call for the abandonment of the Modern Synthesis. The collection will be of interest to researchers and students in evolutionary biology, and the philosophy and history of the biological sciences. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Astrology, Computers, and the VolksgeistDenis DuttonCarroll Righter is not a name you will recognize, unless, perhaps, you’re old enough and you grew up reading the Los Angeles Times. Righter was the Times’s astrologer, and encountering his name recently brought back a couple of memories from the early 1950s. I remember finding it strange that a man (he was pictured alongside his column) was called Carroll, though he didn’t spell (...) it like the girl who lived across the street. But especially I recall the fun we had when my father would read the horoscopes out loud and we’d compare them with the day’s events. Ours was a tough family for an astrologer to please, with rather different things happening to too many Aquarians, and a robust skepticism about anything of the sort later to be called “New Age.”How could I know that while we laughed and debated, somewhere else out there in the urban sprawl, Righter’s prognostications were being subjected to subtle and portentous analysis by that kingpin of the Frankfurt School, Theodor W. Adorno? Mirabile dictu, Adorno was living in L.A. at the time, and we now have his examination of Righter in The Stars Down to Earth, and Other Essays on the Irrational in Culture, edited with an excellent introduction by Stephen Crook (Routledge, $16.95). The result seems, now in the fullness of time, of mixed value and relevance. Adorno has produced an admirably accessible rhetoric of astrology, what he terms “content analysis.” In this, he is finding out for himself about the so-called cold-reading techniques of psychic consultation, practices long known to magicians and astrologers and only really understood by psychologists since Bertram Forer’s work in the 1940s. But beyond that, Adorno uses astrology to support and exemplify his theory of authoritarian irrationalism. As you might expect, this is more questionable. [End Page 424]To be sure, there are many intriguing observations throughout this mostly readable essay. In a passage perhaps even more true today than when it was written, Adorno says that a “climate of semi-erudition is the fertile breeding ground for astrology.” He refers to people who have gone just beyond the naive acceptance of the authority of science, but who don’t know enough, or who have not sufficiently developed “the power of thinking,” that they can replace such acceptance with anything better: “The semi-erudite vaguely wants to understand and is also driven by the narcissistic wish to prove superior to the plain people but he is not in a position to carry through complicated and detached intellectual operations.” In other words, quantum mechanics is pretty tough, but astrology offers sophisticated understanding of all reality in a few easy steps. Besides, astronomy is about those remote stars and planets out there—rather cold and impersonal. In Adorno’s apt title phrase, astrology brings it all down to earth, because it’s about the single most important thing in the universe: me. In an analogy that isn’t too far-fetched, he says that to the semi-erudite individual “astrology, just as other irrational creeds like racism, provides a short-cut by bringing the complex to a handy formula and offering at the same time the pleasant gratification that he who feels excluded from educational privileges nevertheless belongs to the minority of those who are ‘in the know.’” Someone once remarked that Scientology boosts self-esteem largely by giving semi-educated, degreeless persons impressive certificates to hang on their walls, and Adorno is right that there’s a similar syndrome at work with most New Age esoterica, including astrology. (In literary theory, there are no certificates, of course—you just have to learn the jargon.)Much to his credit, Adorno independently identifies many of the features of cold reading described by Forer and later writers, such as the persistent tendency of the client to personalize the general message. Of Righter’s “Follow up that intuition of yours,” or “Display that keen mind of yours,” Adorno says, “People who have any affinity at all to occultism are usually prepared to react to the information they are craving in such a way... (shrink)

Individual humans as well as human communities interact in a great variety of ways and, in essence, Unesco's Silk Roads Major Project endeavors to shed light on the cultural interactions along the trade routes linking various Eurasian civilizations. The term Silk Road or Roads conjures up visions of caravans laden with rare goods, carrying them from the distant, perhaps even the so-called “mysterious”, East towards the Western World. This general impression is partially created by the word “silk”, name of a (...) commodity generally and correctly linked with China where it was first produced. It is good to remember that a “Silk Road” is a historic fiction, invented in the nineteenth century by the German geographer von Richthofen to call attention to the existence of, first and foremost, commercial contacts between China and the Roman Empire. Silk was but one of the many goods circulating all along the many roads criss-crossing the great Eurasian space. This short essay will provide some information on the languages used along the land arteries of communication between East and West. (shrink)

“Kitsch” has sometimes been used (for example, by Harold Rosenberg) to refer to virtually any form of popular art or entertainment, especially when sentimental. But though much popular art is cheap and crude, it is at least direct and unpretentious. On the other hand, a persistent theme in the history of the usage of “kitsch,” going back to the word’s mid-European origins, is pretentiousness, especially in reference to objects that ape whatever is conventionally viewed as high art. As Arnold Hauser (...) has remarked, kitsch differs from merely popular forms in its insistence on being taken seriously as art. Kitsch can thus be defined as a kind of pseudo-art which has an essential attribute of borrowing or parasitism, and whose essential function is to flatter, soothe, and reassure its viewer and consumer. (shrink)

This paper attempts to explain the abiding appeal of the suspicion that Wittgenstein is a conservative thinker. Among Wittgensteinians, there is a growing orthodoxy which takes the notion of 'Wittgenstein's conservatism' to be 'nutty' (Diamond 1991 p34). One justification for this opinion is that the charge of conservatism has typically been defended on the basis of highly implausible interpretations of Wittgenstein. However, the critical core of the conservatism charge has been mislocated by Wittgenstein's supporters and by most of his critics. (...) No conservative theses are defended in his work. But in challenging the conceptual tools so often used in justifying criticism of our practices, Wittgenstein appears to abandon us to a conservatism by default. To understand this charge, we must broaden the context within which Wittgenstein's work is normally discussed. Odd as it may sound, what Wittgenstein actually says may only be one (and perhaps not the most important) consideration that we must bear in mind in assessing whether he is a conservative thinker. (shrink)

John Searle upholds the idea of a “background” of intentionality. In his view there is an ensemble of non-representational (or non-intentional) mental capacities that make every form of intentionality possible (that is to say, without these mental capacities there would not be any beliefs, desires, intentions, etc.). I examine both his reasons to believe that there are non-representational mental capacities and the arguments he gives in support of the most important claim (according to him) that an intentional state cannot be (...) this particular state unless the said “background” existe. (shrink)

Dans les Recherches philosophiques, Wittgenstein consacre une série importante de remarques au problème du «langage privé». Un langage privé, d'après la définition qu'il donne dans ces passages, est un langage dont les mots sont censés se référer «à ce dont seul celui qui parle peut avoir connaissance; à ses sensations immédiates et privées […]». Le résultat bien connu de sa discussion est que non seulement il n'y a pas en fait, mais il n'est pas possible qu'il existe un tel langage; (...) pour lui, un langage doit être nécessairement «public», c'est-à-dire parlé par plusieurs locuteurs. De l'avis de tous les commentateurs, ces remarques sur le thème du langage privé occupent une place centrale dans les Recherches, mais les opinions diffèrent sur la façon dont on devrait les interpréter. Dans ce qui suit, je défends l'interprétation d'après laquelle sa discussion doit se comprendre en la replaçant dans le cadre d'une philosophie du langage. De façon plus précise, j'essayerai de montrer quel est le lien entre l'«argument du langage privé», comme le désignent les interprètes, l'argument qu'il avance contre l'idée qu'il pourrait exister un langage comme celui-là, et ses vues sur le langage et la signification. Il y a en réalité, je pense, non pas un mais deux «arguments du langage privé» et les deux arguments, que je vais exposer, visent indirectement à mettre en relief une conception d'ensemble du langage, celle qu'il met de l'avant dans ses Recherches, et non pas seulement, de façon plus étroite, une conception ayant trait au langage des sensations. Comme je le dirai aussi plus loin, cette image du langage qu'offre Wittgenstein dans les Recherches soulève une difficulté, si je l'interprète correctement, mais celle-ci n'enlève rien à l'intérêt philosophique de ses remarques. (shrink)

The explanatory power of structures in analytical sociologists’ agent-based models brings into question methodological individualism. We defend that from an explanatory point of view, the syntactic properties of models require semantic conditions of interpretation drawn from a conceptual research framework; in such a framework, social/relational structures have only partial, explanatory power ; and taking the explanation further through generative mechanism modeling necessitates calling upon methodological individualism’s generic framework of interpretation that relies on social actors’ rational capacity. According to this interpretive (...) framework, forces in action in society are governed by the subjective meaning of/the reasons for individual actions. (shrink)

Building Better Health Care Leadership for Canada explains the development and implementation of the Executive Training in Research Application program. Managed and funded by the Canadian Health Services Research Foundation in partnership with the Canadian Medical Association, the Canadian Nursing Association, and the Canadian College of Health Care executives, EXTRA is a two-year national fellowship program that uses the principles of adult learning theory as well as practical projects to educate senior health care leaders in making more consistent use of (...) research evidence in their management roles. Fellows apply the theory learned in residency sessions and educational activities to projects within their home organizations. The authors identify the imperative for better use of evidence, outline the core elements of the curriculum, and capture the real-world experience of regional leaders and fellows involved in making specific changes informed by research-based evidence within their organization. Contributors include Jean-Louis Denis, Terrence Sullivan, Owen Adams, Malcolm Anderson, Lynda Atack, Robert Bell, Sam G Campbell, Sylvie Cantin, Ward Flemons, Dorothy Forbes, J. Sonja Glass, Paula Goering, Karen Golden-Biddle, Jeffrey S. Hoch, Paul Lamarche, Ann Langley, John N. Lavis, Jonathan Lomas, Margo Orchard, Raynald Pineault, Brian D. Postl, Christine Power, Trish Reay, Jean Rochon, Denis A. Roy, Andrea Seymour, Samuel B. Sheps, Micheline Ste-Marie, Nina Stipich, David Streiner, Carl Taillon, and Muriah Umoquit. (shrink)

Does the matter of the sensible world, for Plotinus as for Plato and Aristotle, exist without a cause of its existence? Long divided on the answer to that question, scholarly opinion now veers in favour of a derivation of matter from principles prior to matter, with disagreement limited to the details of the theory. What exactly is implied by the various passages of the Enneads where Plotinus writes of soul or physis in relation to `darkness' and `non-being', matter and form? (...) In the pages that follow, I argue that the soul's `making' of a `non-being' that by implication is matter, in Enn. III 9 [13] 3, is logically antecedent to the `making' of `visible form' ascribed to physis in Enn. III 8 [30] 2. A detailed study of the context and the syntax of the latter passage shows that, contrary to an interpretation put forward recently in this Journal, the two `makings' cannot be the same. (shrink)

The realization of dwindling fossil fuel supplies and their adverse environmental impacts has accelerated research and development activities in the domain of renewable energy sources and technologies. Global energy demand is expected to rise during the next few decades, and the majority of today's energy is based on fossil fuels. Alternative energy sources and technologies can play a vital role in lowering or eliminating our reliance on fossil fuels. However, such a transition will require a large investment and will not (...) be reversible. The benefits of hydrogen and other liquid fuels as transportation fuels are not marginal, but the real urgency in greenhouse gas reductions and fossil fuel replacement should not be translated into an energy infrastructure based on unsustainable sources in the long run. It is wise to examine each option thoroughly and objectively now and discard those with little potential so our focus and effort may be placed elsewhere. (shrink)

The authors examine several issues in teaching phenomenology (1) to advanced researchers who are doing qualitative research using phenomenological interview methods in disciplines such as psychology, nursing, or education, and (2) to advanced researchers in the cognitive neurosciences. In these contexts, the term “teaching” needs to be taken in a general and nondidactic way. In the case of the first group, it involves guiding doctoral students in their conception and design of a qualitative methodology that is properly phenomenological. In the (...) case of the second, it is more concerned with explaining the relevance of phenomenology to an audience of experimental scientists via conference presentations or published papers. In both cases, however, the challenge is to make clear to the relevant audience what phenomenology is and how it can relate to what they are doing. (shrink)

Around the world, private and public organizations use software called legal expert systems to compute taxes. This software must comply with the laws they are designed to implement. As such, a bug or an error in a program that leads to tax miscalculations can have heavy legal and democratic consequences. However, increasing evidence suggests that some legal expert systems may not comply with the law. Moreover, traditional software development processes mean that legal expert systems are difficult to adapt to the (...) continuous flow of new legislation. To prevent further software decay and to reconcile these systems with the growing demand for algorithmic transparency, we argue that there is a need for a new development process for legal expert systems. This new system must be built to comply with the law, in particular the GDPR. It must also respect democratic transparency. For these reasons, we present a solution built by lawyers and computer scientists: C atala, a new programming language coupled with a pair programming development process. (shrink)

Much innovation has taken place in the development of medical schools and licensure exam processes across the African continent. Still, little attention has been paid to education that enables the multidisciplinary, critical thinking needed to understand and help shape the larger social systems in which health care is delivered. Although more than half of medical schools in Canada, the United Kingdom, and the United States offer at least one medical humanities course, this is less common in Africa. We report on (...) the “liberal arts approach” to medical curricula undertaken by the University of Global Health Equity beginning in 2019. The first six-month semester of the curriculum, called Foundations in Social Medicine, includes courses in critical thinking and communication, African history and global political economy, medical anthropology and social medicine, psychology and health, gender and social justice, information technology and health, and community-based training. Additionally, an inquiry-based pedagogy with relatively small classes is featured within an overall institutional culture that emphasizes health equity. We identify key competencies for physicians interested in pursuing global health equity and how such competencies relate to liberal arts integration into the African medical school curriculum and pedagogical approach. We conclude with a call for a research agenda that can better evaluate the impact of such innovations on physicians’ education and subsequent practices. (shrink)

This paper presents an experimental study investigating artificial grammar learning (AGL) in monolingual and bilingual children, with and without dyslexia, using an original methodology. We administered a serial reaction time (SRT) task, in the form of a modified Simon task, in which the sequence of the stimuli was manipulated according to the rules of a simple Lindenmayer grammar (more specifically, a Fibonacci grammar). By ensuring that the subjects focused on the correct response execution at the motor stage in presence of (...) congruent or incongruent visual stimuli, we could meet the two fundamental criteria for implicit learning: the absence of an intention to learn and the lack of awareness at the level of resulting knowledge. The participants of our studies were four groups of 10-year-old children: 30 Italian monolingual typically developing children, 30 bilingual typically developing children with Italian L2, 24 Italian monolingual dyslexic children and 24 bilingual dyslexic children with Italian L2. Participants were administered the modified Simon task developed according to the rules of the Fibonacci grammar and tested with respect to the implicit learning of three regularities: (i) a red is followed by a blue; (ii) a sequence of two blues is followed by a red and (iii) a blue can be followed either by a red or by a blue. Results clearly support the hypothesis that implicit learning took place, since participants of all groups became increasingly sensitive to the structure of the input, implicitly learning the sequence of the trials and thus appropriately predicting the occurrence of the relevant items, as manifested by faster reaction times in predictable trials. Moreover, group differences were found, with bilinguals being overall faster than monolinguals and dyslexics less accurate than controls. Finally, an advantage of bilingualism in dyslexia was found, with bilingual dyslexics performing consistently better than monolingual dyslexics and, in some conditions, at the level of the two control groups. These results are taken to suggest that bilingualism should be supported also among linguistically impaired individuals. (shrink)

We begin this article by delineating the explanatory gaps left by prevailing gene‐focused approaches in our understanding of phenotype determination, inheritance, and the origin of novel traits. We aim not to diminish the value of these approaches but to highlight where their implementation, despite best efforts, has encountered persistent limitations. We then discuss how each of these explanatory gaps can be addressed by expanding research foci to take into accountbiological agency—the capacity of living systems at various levels to participate in (...) their own development, maintenance, and function by regulating their structures and activities in response to conditions they encounter. Here we aim to define formally what agency and agents are and—just as importantly—what they are not, emphasizing that agency is an empirical property connoting neither intention nor consciousness. Lastly, we discuss how incorporating agency helps to bridge explanatory gaps left by conventional approaches, highlight scientific fields in which implicit agency approaches are already proving valuable, and assess the opportunities and challenges of more systematically incorporating biological agency into research programs. (shrink)

Earthquakes, which can cause widespread territorial and socio-economic destruction, are life-threatening, unexpected, unpredictable and uncontrollable events caused by the shaking of the surface of the earth. The psychological consequences, such as PTSD, anxiety, depression, and suicidal ideation, are well-known to clinicians and researchers. This study was conducted with the aim of evaluating the use of the Eye Movement Desensitization and Reprocessing (EMDR) Integrative Group Treatment Protocol (IGTP) on a sample of adolescents, after the earthquake in Central Italy on 24 August (...) 2016. The objective of the EMDR intervention was to reduce PTSD symptoms. Before and after EMDR, specific assessment to find changes in PTSD symptoms was made using the IES-R (Impact of Event Scale Revised) and through the analyses of the Subjective Units of Disturbance (SUD). The EMDR treatment was given in three sessions (T1, T2, T3), each lasting 90 minutes, and the results at follow-up phase (T4) were also monitored. The results are very encouraging, showing significantly reduced PTSD symptoms in the majority of the subjects. The clinical implications and limitations will be discussed. (shrink)

La naissance constitue pour toute famille un bouleversement identitaire. Dans ce contexte, le « devenir grand-parent » est encore peu étudié. Les auteurs ont mené plusieurs entretiens conjointement chez des parents et grands-parents dans une population tout-venant au Québec. Les résultats illustrent les enjeux identitaires qui surgissent autour de la naissance entre les parents et leurs propres parents. Les parents s’expriment sur l’attente quant au soutien que pourraient apporter ces derniers. Les grands-parents, qui semblent plutôt en attente de relations avec (...) le bébé, passeraient par ce soutien pour trouver leur propre place dans l’économie familiale. Avec des différences selon les sexes, les grands-parents concourent ainsi à construire grâce à cet étayage un berceau psychique familial qui réunit dans un premier cercle les parents avec leur bébé. En périnatalité, cette « fonction » grand-parentale permettrait d’envisager la spécificité d’un second cercle autour du bébé, propre également aux interventions des professionnels. (shrink)

In this paper, we demonstrate (1) how harnessing stochasticity can be the basis of creative agency; (2) that such harnessing can resolve the apparent conflict between reductionist (micro-level) accounts of behaviour and behaviour as the outcome of rational and value-driven (macro-level) decisions; (3) how neurophysiological processes can instantiate such behaviour; (4) The processes involved depend on three features of living organisms: (a) they are necessarily open systems; (b) micro-level systems therefore nest within higher-level systems; (c) causal interactions must occur across (...) all the boundaries between the levels of organization. The higher levels constrain the dynamics of lower levels. The experimental evidence and theoretical arguments are shown to be consistent with previous research on the neuronal mechanisms of conscious choice, and with the interconnected multi-level processes by which organisms harness stochasticity, whether conscious or unconscious. (shrink)

This special issue focuses on the theoretical, empirical and practical integrations between embodied cognition theory and educational science. The key question is: Can EC constitute a new theoretical framework for educational science and practice? The papers of the special issue support the efforts of those interested in the role of EC in education and in the epistemological convergence of EC and educational science. They deal with a variety of relevant topics in education and offer a focus on the role of (...) the body and embodied experience in learning and educational settings. In conclusion, some further topics are suggested that will need to be investigated in the future, such as a critical evaluation of the possibility for an epistemological alliance between educational theory and embodied cognition, and the contribution that enactive cognition can provide to educational systems, organizations, institutions and policies. (shrink)

La dynamique des sciences se deploie selon des temporalites multiples qui possedent leurs propres rythmes. De ce point de vue, l'exercice qui consiste a scander en decennies l'histoire de la logique et des sciences formelles est perilleux. Peut-on aller au-dela et tenter de donner sens a cette decennie des annees trente? La fin du logicisme, l'avenement de nouvelles logiques, le developpement du formalisme, ses limitations internes, sa critique externe et les approches formelles du langage sont six traits caracteristiques explores dans (...) ce recueil d'articles qui font apparaitre l'eloignement ainsi que la proximite des annees trente et de cette fin de siecle. (shrink)

« La matière est-elle identique à l'altérilé ? » Plotin se pose cette question au commencement du dernier chapitre de son traité Sur la matière (Enn., II 4 [12] 16). « Plutôt non », répond-il. « Elle est en revanche identique à cette partie de l'altérité qui s'oppose aux êtres proprement dits. » En s'exprimant de la sorte, Plotin fait allusion à un passage du Sophiste (258 E 2-3). Son allusion suppose pourtant l'existence d'un texte qui n'est pas attesté dans (...) les manuscrits. Cette différence textuelle implique un changement fondamental de doctrine, dont les éditeurs modernes ne se sont pas avisés. (shrink)

The form of beauty is the ultimate correlate of love in Socrates' account of Diotima's teaching in the Symposium . To arrive at this insight, Socrates aims to show the `absurdity' of adopting any more specific correlate as a definition of the very nature of love. Were love defined as love `for a father or a mother', we could never love anyone who was not our father or our mother. An obvious absurdity.

We construct a class of relations on computable structures whose degree spectra form natural classes of degrees. Given any computable ordinal and reducibility r stronger than or equal to m-reducibility, we show how to construct a structure with an intrinsically invariant relation whose degree spectrum consists of all nontrivial r-degrees. We extend this construction to show that can be replaced by either or.